Regulatory
Part:BBa_K639002:Experience
Designed by: Espen Bang Leistad Group: iGEM11_NTNU_Trondheim (2011-08-26)
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Applications of BBa_K639002
Previous studies have shown that the rrnB P1 promoter is downregulated by ppGpp [1], which is an alarmone involved in the stringent response in bacteria. Our project involved using the rrnB P1 promoter as a stress-sensor, where it would stop expressing an inhibitor for a second promoter, thus giving a signal.
[1] Magnusson, Lisa U., Farewell, Anne, Nyström, Thomas: "ppGpp: a global regulator in Escherichia Coli", 2005
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